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1

A systematic review of health economic evaluations of proton beam therapy for adult cancer: Appraising methodology and quality

Jones, David A., Smith, Joel, Mei, Xue W., Hawkins, Maria A., Maughan, Tim, van den Heuvel, Frank, Mee, Thomas, Kirkby, Karen, Kirkby, Norman, Gray, Alastair

Journal:

Clinical and Translational Radiation Oncology

Year:

2020

Language:

english

File:

PDF, 590 KB

english, 2020

2

Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies

Cristina Sánchez-Sixto, Verónica F. V. Prazeres, Luis Castedo, Se Won Suh, Heather Lamb, Alastair R. Hawkins, Francisco Javier Cañada, Jesús Jiménez-Barbero, Concepción González-Bello

Journal:

Year:

2008

Language:

english

File:

PDF, 746 KB

english, 2008

3

Poly(4- and 5-acrylamidosalicylic acids). Part V. Effect of counter anion and salicylate complex stability on cation exchange from aqueous solution

Alastair W. Nicol, Alan Hawkins, John F. Kennedy

Journal:

Hydrometallurgy

Year:

1977

Language:

english

File:

PDF, 570 KB

english, 1977

4

The slow step of folding of Staphylococcus aureus PC1 β-lactamase involves the collapse of a surface loop rate limited by the Trans to Cis isomerization of a non-proline peptide bond

Kerry A. Wheeler, Alastair R. Hawkins, Roger Pain, Richard Virden

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1998

Language:

english

File:

PDF, 122 KB

english, 1998

5

ChemInform Abstract: Synthesis of 4-Deoxyquinic, 4-Deoxyshikimic and 4-Deoxy-3-dehydroshikimic Acid.

Concepcion Gonzalez-Bello, John R. Coggins, Alastair R. Hawkins, Chris Abell

Journal:

Year:

1999

File:

PDF, 25 KB

1999

6

Determination of the Bound Conformation of a Competitive Nanomolar Inhibitor of Mycobacterium tuberculosis Type II Dehydroquinase by NMR Spectroscopy

Verónica F. V. Prazeres, Cristina Sánchez-Sixto, Luis Castedo, Ángeles Canales, Francisco Javier Cañada, Jesús Jiménez-Barbero, Heather Lamb, Alastair R. Hawkins, Concepción González-Bello

Journal:

Year:

2006

Language:

english

File:

PDF, 492 KB

english, 2006

7

Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase

Verónica F. V. Prazeres, Cristina Sánchez-Sixto, Luis Castedo, Heather Lamb, Alastair R. Hawkins, Alan Riboldi-Tunnicliffe, John R. Coggins, Adrian J. Lapthorn, Concepción González-Bello

Journal:

Year:

2007

Language:

english

File:

PDF, 646 KB

english, 2007

8

Cover Picture: Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase (ChemMedChem 2/2007)

Verónica F. V. Prazeres, Cristina Sánchez-Sixto, Luis Castedo, Heather Lamb, Alastair R. Hawkins, Alan Riboldi-Tunnicliffe, John R. Coggins, Adrian J. Lapthorn, Concepción González-Bello

Journal:

Year:

2007

File:

PDF, 43 KB

2007

9

2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase

Verónica F. V. Prazeres, Luis Castedo, Heather Lamb, Alastair R. Hawkins, Concepción González-Bello

Journal:

Year:

2009

Language:

english

File:

PDF, 538 KB

english, 2009

10

Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)-2-Benzyl-3-dehydroquinic Acids

Antonio Peón, Dr. José M. Otero, Lorena Tizón, Verónica F. V. Prazeres, Dr. Antonio L. Llamas-Saiz, Dr. Gavin C. Fox, Dr. Mark J. van Raaij, Dr. Heather Lamb, Prof. Dr. Alastair R. Hawkins, Prof. Dr.

Journal:

Year:

2010

Language:

english

File:

PDF, 1.29 MB

english, 2010

11

Tetrahydrobenzothiophene Derivatives: Conformationally Restricted Inhibitors of Type II Dehydroquinase

Sonia Paz, Lorena Tizón, Dr. José M. Otero, Dr. Antonio L. Llamas-Saiz, Dr. Gavin C. Fox, Dr. Mark J. van Raaij, Dr. Heather Lamb, Prof. Dr. Alastair R. Hawkins, Dr. Adrian J. Lapthorn, Prof. Dr. Luis

Journal:

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

12

A thermodynamic study of the reactions: {2-dehydro-3-deoxy-d-arabino-heptanoate 7-phosphate(aq)=3-dehydroquinate(aq) + phosphate(aq)} and {3-dehydroquinate(aq)=3-dehydroshikimate(aq) + H2O(l)}

Yadu B. Tewari, Robert N. Goldberg, Alastair R. Hawkins, Heather K. Lamb

Journal:

The Journal of Chemical Thermodynamics

Year:

2002

Language:

english

File:

PDF, 338 KB

english, 2002

13

Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids

Emily J Parker, Concepción González Bello, John R Coggins, Alastair R Hawkins, Chris Abell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 163 KB

english, 2000

14

The transcription repressor NmrA is subject to proteolysis by three Aspergillus nidulans proteases

Xiao Zhao, Samantha L. Hume, Christopher Johnson, Paul Thompson, Junyong Huang, Joe Gray, Heather K. Lamb, Alastair R. Hawkins

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 490 KB

english, 2010

15

Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: An unusual Type II glyoxalase

Anna L. Stamp, Paul Owen, Kamel El Omari, Charles E. Nichols, Michael Lockyer, Heather K. Lamb, Ian G. Charles, Alastair R. Hawkins, David K. Stammers

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 592 KB

english, 2010

16

Kinetic analysis of the interaction between the QutA and QutR transcription-regulating proteins

Carys Watts, Shi Ming Si-Hoe, Heather K. Lamb, Lisa J. Levett, John R. Coggins, Alastair R. Hawkins

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2002

Language:

english

File:

PDF, 182 KB

english, 2002

17

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases

Charlie E. Nichols, Heather K. Lamb, Mike Lockyer, Ian G. Charles, Susan Pyne, Alastair R. Hawkins, David K. Stammers

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 3.34 MB

english, 2007

18

Crystallographic and microcalorimetric analyses reveal the structural basis for high arginine specificity in the Salmonella enterica serovar Typhimurium periplasmic binding protein STM4351

Anna L. Stamp, Paul Owen, Kamel El Omari, Michael Lockyer, Heather K. Lamb, Ian G. Charles, Alastair R. Hawkins, David K. Stammers

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2011

Language:

english

File:

PDF, 378 KB

english, 2011

19

Sequence of thePhytophthora infestansglyceraldehyde-3-phosphate dehydrogenase-encoding gene (gpdA)

Richard P. Moon, Shiela E. Unkles, James M. Duncan, Alastair R. Hawkins, James R. Kinghorn

Journal:

Plant Molecular Biology

Year:

1992

Language:

english

File:

PDF, 146 KB

english, 1992

20

In vivo overproduction of the pentafunctionalarompolypeptide inAspergillus nidulansaffects metabolic flux in the quinate pathway

Heather K. Lamb, Clive R. Bagshaw, Alastair R. Hawkins

Journal:

Molecular Genetics and Genomics

Year:

1991

Language:

english

File:

PDF, 1.03 MB

english, 1991

21

TheMycobacterium tuberculosisshikimate pathway genes: Evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases

Thomas Garbe, Spiros Servos, Alastair Hawkins, George Dimitriadis, Douglas Young, Gordon Dougan, Ian Charles

Journal:

Molecular Genetics and Genomics

Year:

1991

Language:

english

File:

PDF, 1.02 MB

english, 1991

22

Overproduction of, and interaction within, bifunctional domains from the amino- and carboxy-termini of the pentafunctional AROM protein ofAspergillus nidulans

Jonathan D. Moore, Alastair R. Hawkins

Journal:

Molecular Genetics and Genomics

Year:

1993

Language:

english

File:

PDF, 1.62 MB

english, 1993

23

Spatial and biological characterisation of the complete quinic acid utilisation gene cluster inAspergillus nidulans

Heather K. Lamb, Alastair R. Hawkins, Melanie Smith, Ian J. Harvey, John Brown, Geoffrey Turner, Clive F. Roberts

Journal:

Molecular Genetics and Genomics

Year:

1990

Language:

english

File:

PDF, 802 KB

english, 1990

24

Nucleotide sequence and regulation of expression of theAspergillus nidulans gdhA gene encoding NADP dependent glutamate dehydrogenase

Alastair R. Hawkins, Sarah Jane Gurr, Paul Montague, James R. Kinghorn

Journal:

Molecular Genetics and Genomics

Year:

1989

Language:

english

File:

PDF, 765 KB

english, 1989

25

Molecular organisation of the quinic acid utilization (QUT) gene cluster inAspergillus nidulans

Alastair R. Hawkins, Heather K. Lamb, Melanie Smith, John W. Keyte, Clive F. Roberts

Journal:

Molecular Genetics and Genomics

Year:

1988

Language:

english

File:

PDF, 1021 KB

english, 1988

26

The complexAromlocus ofAspergillus nidulans

Alastair R. Hawkin

Journal:

Current Genetics

Year:

1987

Language:

english

File:

PDF, 689 KB

english, 1987

27

Isolation and identification of theAspergillus nidulans gdhAgene encoding NADP-linked glutamate dehydrogenase

Sarah Jane Guff, Alastair R. Hawkins, Constantin Drainas, James R. Kinghorn

Journal:

Current Genetics

Year:

1986

Language:

english

File:

PDF, 493 KB

english, 1986

28

Cloning and characterization of the three enzyme structural genesQUTB,QUTCandQUTEfrom the quinic acid utilization gene cluster inAspergillus nidulans

Alastair R. Hawkins, Antonio J. Francisco, Clive F. Roberts

Journal:

Current Genetics

Year:

1985

Language:

english

File:

PDF, 912 KB

english, 1985

29

Cloning and expression inEscherichia coliK-12 of the biosynthetic dehydroquinase function of thearomcluster gene from the eucaryote,Aspergillus nidulans

James R. Kinghorn, Alastair R. Hawkins

Journal:

Molecular Genetics and Genomics

Year:

1982

Language:

english

File:

PDF, 817 KB

english, 1982

30

Identification and isolation of a putative permease gene in the quinic acid utilization (QUT) gene cluster ofAspergillus nidulans

Hayley A. Whittington, Susan Grant, Clive F. Roberts, Heather Lamb, Alastair R. Hawkins

Journal:

Current Genetics

Year:

1987

Language:

english

File:

PDF, 417 KB

english, 1987

31

Genetical and biochemical aspects of quinate breakdown in the filamentous fungusAspergillus nidulans

Alastair R. Hawkins, Norman H. Giles, James R. Kinghorn

Journal:

Biochemical Genetics

Year:

1982

Language:

english

File:

PDF, 713 KB

english, 1982

32

Evidence for opposite stereochemical courses for the reaction catalysed by type I and type II dehydrocquinases

Andrea Shneier, Joanna Harris, Colin Kleanthous, John R. Coggins, Alastair R. Hawkins, Chris Abell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 295 KB

english, 1993

33

10.1038/28431

Brown, Katherine A., Carpenter, Elisabeth P., Hawkins, Alastair R., Frost, John W.

Journal:

Year:

1998

Language:

english

File:

PDF, 328 KB

english, 1998

34

10.1038/9287

Coggins, John R., Sawyer, Lindsay, Gourley, David G., Shrive, Annette K., Polikarpov, Igor, Krell, Tino, Hawkins, Alastair R., Isaacs, Neil W.

Journal:

Natural Structural Biology

Year:

1999

Language:

english

File:

PDF, 1.03 MB

english, 1999

35

Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding

Masayo Kotaka, Balvinder Dhaliwal, Jingshan Ren, Charles E. Nichols, Richard Angell, Michael Lockyer, Alastair R. Hawkins, David K. Stammers

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 678 KB

english, 2006

36

Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: factors influencing their inhibition potency

Blanco, Beatriz, Sedes, Antía, Peón, Antonio, Lamb, Heather, Hawkins, Alastair R., Castedo, Luis, González-Bello, Concepción

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 2.80 MB

english, 2012

37

Interaction between relaxase MbeA and accessory protein MbeC of the conjugally mobilizable plasmid ColE1

Athanasia Varsaki, Heather K. Lamb, Olga Eleftheriadou, Elpiniki Vandera, Paul Thompson, Gabriel Moncalián, Fernando de la Cruz, Alastair R. Hawkins, Constantin Drainas

Journal:

Year:

2012

Language:

english

File:

PDF, 576 KB

english, 2012

38

A genome wide scan for association with multiple sclerosis in a N. Irish case control population

Shirley Heggarty, Stephen Sawcer, Stanley Hawkins, Gavin McDonnell, Aidan Droogan, Koen Vandenbroeck, Michael Hutchinson, Efrosini Setakis, Alastair Compston, Colin Graham

Journal:

Journal of Neuroimmunology

Year:

2003

Language:

english

File:

PDF, 88 KB

english, 2003

39

Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus

Louise E Bird, Jingshan Ren, Jiancheng Zhang, Neale Foxwell, Alastair R Hawkins, Ian G Charles, David K Stammers

Journal:

Year:

2002

Language:

english

File:

PDF, 807 KB

english, 2002

40

Domain structure and interaction within the pentafunctional arom polypeptide

Alastair R. HAWKINS, Melanie SMITH

Journal:

Year:

1991

Language:

english

File:

PDF, 1.06 MB

english, 1991

41

The Molecular Biology of Multidomain Proteins Selected Examples

Alastair R. Hawkins, Heather K. Lamb

Journal:

Year:

1995

Language:

english

File:

PDF, 1.53 MB

english, 1995

42

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues‡

Prazeres, Verónica F. V., Tizón, Lorena, Otero, José M., Guardado-Calvo, Pablo, Llamas-Saiz, Antonio L., van Raaij, Mark J., Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., González-Bello, Con

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.69 MB

english, 2010

43

A single DNA-binding protein from Pseudomonas aeruginosa homologous to proteins NS1 and NS2 (HU proteins) of Escherichia coli and other bacteria

Alastair R. Hawkins, John C. Wootton

Journal:

Year:

1981

Language:

english

File:

PDF, 365 KB

english, 1981

44

Chloramphenicol acetyltransferase gene of staphylococcal plasmid pC221: Nucleotide sequence analysis and expression studies

William V. Shaw, Daniel G. Brenner, Stuart F.J. LeGrice, Sarah E. Skinner, Alastair R. Hawkins

Journal:

Year:

1985

Language:

english

File:

PDF, 627 KB

english, 1985

45

Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinase

Balvinder Dhaliwal, Charles E. Nichols, Jingshan Ren, Michael Lockyer, Ian Charles, Alastair R. Hawkins, David K. Stammers

Journal:

Year:

2004

Language:

english

File:

PDF, 284 KB

english, 2004

46

Structural Analysis of the Recognition of the Negative Regulator NmrA and DNA by the Zinc Finger from the GATA-Type Transcription Factor AreA

Masayo Kotaka, Christopher Johnson, Heather K. Lamb, Alastair R. Hawkins, Jingshan Ren, David K. Stammers

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.37 MB

english, 2008

47

Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2 S )- and (2 R )-2-Benzyl-3-dehydroquinic Acids

Lence, Emilio, Tizón, Lorena, Otero, José M., Peón, Antonio, Prazeres, Verónica F. V., Llamas-Saiz, Antonio L., Fox, Gavin C., van Raaij, Mark J., Lamb, Heather, Hawkins, Alastair R., González-Bello,

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.61 MB

english, 2013

48

Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein

Alison Park, Heather K. Lamb, Charlie Nichols, Jonathan D. Moore, Katherine A. Brown, Alan Cooper, Ian G. Charles, David K. Stammers, Alastair R. Hawkins

Journal:

Protein Science

Year:

2004

Language:

english

File:

PDF, 195 KB

english, 2004

49

Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis

Heather K. Lamb, Jingshan Ren, Alison Park, Christopher Johnson, Kris Leslie, Simon Cocklin, Paul Thompson, Christopher Mee, Alan Cooper, David K. Stammers, Alastair R. Hawkins

Journal:

Protein Science

Year:

2004

Language:

english

File:

PDF, 261 KB

english, 2004

50

A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors

Tizón, Lorena, Otero, José M., Prazeres, Verónica F. V., Llamas-Saiz, Antonio L., Fox, Gavin C., van Raaij, Mark J., Lamb, Heather, Hawkins, Alastair R., Ainsa, José A., Castedo, Luis, González-B

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.09 MB

english, 2011